Programming gene expression with combinatorial promoters

Programming gene expression with combinatorial promoters

Promoters control the expression of genes in response to one or more transcription factors (TFs). The architecture of a promoter is the arrangement and type of binding sites within it. To understand natural genetic circuits and to design promoters for synthetic biology, it is essential to understand the relationship between promoter function and architecture. We constructed a combinatorial libr...

Forecasting copper price using gene expression programming

Forecasting the prices of metals is important in many aspects of economics. Metal prices are also vital variables in financial models for revenue evaluation, which forms the basis of an effective payment regime using resource policymakers. According to the severe changes of the metal prices in the recent years, the classic estimation methods cannot correctly estimate the volatility. In order to...

Combinatorial Optimization by Gene Expression Programming: Inversion Revisited

Combinatorial optimization problems require combinatorial-specific search operators so that populations of candidate solutions can evolve efficiently. Indeed, several researchers created modifications to the basic genetic operators of mutation and recombination in order to create high performing combinatorial-specific operators. However, it is not known which operators perform better as no syst...

Universal Gene Expression Analysis with Combinatorial Arrays

Combinatorial Control of Gene Expression

The complexity and diversity of eukaryotic organisms are a feat of nature's engineering. Pulling the strings of such an intricate machinery requires an even more masterful and crafty approach. Only the number and type of responses that they generate exceed the staggering proportions of environmental signals perceived and processed by eukaryotes. Hence, at first glance, the cell's sparse stockpi...